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Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes

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Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes
Komal Kampasi, Daniel F English, John Seymour, Eran Stark, Sam McKenzie, Mihály Vöröslakos, György Buzsáki, Kensall D Wise, Euisik Yoon
Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings. Genetically-identified classes of neurons are optically manipulated, though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution. We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo. We describe the design, fabrication, and assembly of low-noise, multisite/multicolor optoelectrodes.
2018-01-01
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