Manipulations refers to various methods and techniques used to alter, control, or influence neural activity, brain functions, or behaviors in experimental settings. These manipulations are crucial for understanding the mechanisms underlying neural processes, the effects of various stimuli or interventions on the brain, and the development of potential therapies for neurological conditions. Manipulations are tied to a dataset and to a subject through actions.
- Deep brain stimulation (DBS): A neurosurgical procedure that involves implanting electrodes in specific areas of the brain to deliver electrical impulses. It's used to treat a variety of neurological conditions, including Parkinson's disease and essential tremor.
- Electromagnetic field stimulation: Involves the use of magnetic or electric fields to modulate neuronal activity. This non-invasive method can influence brain function and is studied for therapeutic potential in psychiatric and neurological disorders.
- Electrical stimulation: The application of electrical currents to neurons or neural tissues to activate or inhibit neural activity. This broad category can include invasive methods like intracortical microstimulation or non-invasive approaches like transcranial direct current stimulation (tDCS).
- Liquid perturbation: Introduces liquids into the brain environment to study the effects of various substances or to physically disrupt brain activity. This can include the injection of drugs, solutions, or other compounds.
- Micro perfusion: A technique that allows the localized delivery of substances directly to a targeted area of the brain through a fine cannula, enabling the study of the effects of drugs or other agents on specific brain regions.
- Optogenetical stimulation: Uses light to control neurons that have been genetically modified to express light-sensitive ion channels. This precise method enables the activation or inhibition of specific neuronal populations with high temporal resolution.
- Pharmacological inhalation: Involves the administration of drugs in vapor form so that they are inhaled and absorbed through the lungs, affecting the brain. This method is used to study the effects of inhaled substances on neural activity and behavior.
- Pharmacological injection: The direct injection of drugs or other substances into the body or directly into brain tissue to study their effects on neural activity, brain function, or behavior.
- Pharmacological superfusion: A technique where drugs are applied directly to neural tissues or cells in a controlled manner, often using a perfusion system, allowing for the study of drug effects on neural activity in vitro.
- Sound stimulation: The use of auditory stimuli to influence brain activity and study the neural mechanisms of hearing, perception, and cognition, as well as the therapeutic effects of sound.
- Thermal perturbation: The application of heat or cold to neural tissue to study the effects of temperature changes on neural activity, function, or structural integrity.
- Transcranial Electrical Stimulation: A non-invasive method that applies electrical currents through the scalp and skull to modulate neuronal activity in the brain, used for research and therapeutic purposes.
- Transcranial Magnetic Stimulation (TMS): A non-invasive technique that uses magnetic fields to induce electrical currents in the brain, capable of modulating neural activity and used for both research and treatment of various neurological and psychiatric conditions.
- Ultra sound stimulation: Utilizes high-frequency sound waves to non-invasively modulate neural activity. This method has potential applications in both research and clinical settings for mapping brain function and treating neurological disorders.
Two-Part submission form and inline form in datasets
The manipulation submission form consists of two parts. In the first part, you must fill in the required fields. Once you click "Create and continue," the entry is created, and you can continue editing it on the second part of the form, which contains all the fields.
Manipulations can also be added directly to a dataset as an inline in the dataset form.
Fields
- Type: the type of manipulation (required).
- Dataset: the type of manipulation (required).
- Actions: The subject the manipulation was performed on (required).
- Description: Description of the manipulation.
- Hardware device: Hardware device used to perform the manipulation.
- Type details: These are type specific fields.
Permissions
Manipulations inherit permissions from projects via the dataset associate with the entry. For more information on permissions, please visit the permissions page.
Manipulation API Access
The API allows for programmable access to manipulations, enabling you to read, edit, and delete manipulations through the API. For details about the manipulation's fields and data structure, refer to the API documentation on the Manipulation API endpoint.
