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Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

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Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway
Noam Nitzan, Sam McKenzie, Prateep Beed, Daniel Fine English, Silvia Oldani, John J. Tukker, György Buzsáki & Dietmar Schmitz
We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.
2020-04-23
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