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Long-duration Hippocampal Sharp Wave Ripples Improve Memory

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Long-duration Hippocampal Sharp Wave Ripples Improve Memory
Fernández-Ruiz A, Oliva A, Fermino de Oliveira E, Rocha-Almeida F, Tinlgey D, Buzsáki G.
Science

Sharp wave ripples in the hippocampus are thought to play a role in memory formation and action planning. Fernández-Ruiz et al. used multisite electrophysiological recordings combined with optogenetic activation of hippocampal pyramidal neurons in rats performing learning tasks. Learning and correct recall in spatial memory tasks were associated with extended sharp wave ripples. Artificially prolonging these ripples improved working memory performance, whereas aborting the late part of ripples decreased performance.

2019-06-13
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