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Artifact-free and high-temporal-resolution in vivo opto-electrophysiology with microLED optoelectrodes

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Artifact-free and high-temporal-resolution in vivo opto-electrophysiology with microLED optoelectrodes
Kanghwan Kim, Mihály Vöröslakos, John P. Seymour, Kensall D. Wise, György Buzsáki & Euisik Yoon
The combination of in vivo extracellular recording and genetic-engineering-assisted optical stimulation is a powerful tool for the study of neuronal circuits. Precise analysis of complex neural circuits requires high-density integration of multiple cellular-size light sources and recording electrodes. However, high-density integration inevitably introduces stimulation artifact. We present minimal-stimulation-artifact (miniSTAR) μLED optoelectrodes that enable effective elimination of stimulation artifact. A multi-metal-layer structure with a shielding layer effectively suppresses capacitive coupling of stimulation signals. A heavily boron-doped silicon substrate silences the photovoltaic effect induced from LED illumination.
2020-04-28
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