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Closed-loop acoustic stimulation enhances sleep oscillations but not memory performance

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Closed-loop acoustic stimulation enhances sleep oscillations but not memory performance
Simon Henin, Helen Borges, Anita Shankar, Cansu Sarac, Lucia Melloni, Daniel Friedman, Adeen Flinker, Lucas C Parra, Gyorgy Buzsaki, Orrin Devinsky, Anli Liu
eNeuro
Prior studies have demonstrated that a closed-loop acoustic pulse paradigm during sleep can enhance verbal memory performance. This technique has widespread scientific and clinical appeal due to its noninvasive nature and ease of application. We tested with a rigorous double-blind design whether this technique could enhance key sleep rhythms associated with sleep-dependent memory performance. We discovered that we could reliably enhance slow and spindle rhythms, but did not improve memory performance in the stimulation condition compared with sham condition. Our findings suggest that enhancing slow-spindle rhythms is insufficient to enhance sleep-dependent learning.
2019-11-01
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