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Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory

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Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory
Yiyao Zhang, Liang Cao, Viktor Varga, Miao Jing, Mursel Karadas, Yulong Li, and György Buzsáki
PNAS

Theta oscillations supported by the medial septum are believed to be a critical mechanism for learning and memory. We report that, in addition to theta oscillations, hippocampal SPW-Rs are important. Enhanced cholinergic activation in the hippocampus during the delay between choices in a spontaneous alternation task abolished SPW-Rs and impaired choice performance in mice. Our findings also demonstrate that the outcome of optogenetic manipulation of a key neurotransmitter, acetylcholine (ACh), depends on the state of the brain at the time of the perturbation.

2021-04-13
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