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Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells

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Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells
Stephanie Rogers, Peter A. Rozman, Manuel Valero, Werner K. Doyle, and György Buzsáki
Chemogenic activation of interneurons can bring about unexpected short-term and long-term changes in circuit dynamics. DREADD activation of all interneuron types suppressed firing of pyramidal cells but, unexpectedly, individual interneurons did not display sustained firing but instead undulated firing rates, interleaved with other interneurons. Despite the tonic suppression of spikes of individual pyramidal neurons, population bursts underlying sharp wave ripples persisted, often with stronger synchrony. Repeated drug application induced progressively weaker changes over days. Such plastic effects of DREADD activation should be taken into account in the interpretation of behavioral consequences.
2021-01-12
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